Sayen began his artistic journey at a young age, studying at the Pennsylvania Academy of the Fine Arts in Philadelphia. He was greatly influenced by the Hudson River School, a group of American landscape painters known for their romantic and detailed portrayals of the natural world. Sayen's early works reflected the influence of this movement, with his paintings often featuring grand vistas, dramatic skies, and meticulous attention to detail.

One of Sayen's notable contributions to the art world was his use of color and light. He had a keen eye for capturing the subtle nuances of natural light and its transformative effect on the landscape. His paintings often featured luminous skies, dappled sunlight filtering through trees, and the interplay of light and shadow. Sayen's skillful use of color and light added depth and vibrancy to his works, creating a sense of realism and capturing the essence of the natural world.

Sayen's art was well-received during his lifetime, and he exhibited his works in prestigious galleries and exhibitions, including the Pennsylvania Academy of the Fine Arts and the National Academy of Design. His paintings were praised for their technical skill, attention to detail, and emotional resonance. Sayen's ability to capture the beauty and majesty of the American landscape resonated with viewers, and his works continue to be admired and celebrated today.